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About Threshold Pharmaceuticals
Threshold is a biotechnology company focused on the discovery and development of drugs targeting Tumor Hypoxia, the low oxygen condition found in microenvironments of most solid tumors as well as the bone marrows of some hematologic malignancies. This approach offers broad potential to treat a variety of cancers. By selectively targeting tumor cells, we are building a pipeline of drugs that hold promise to be more effective and less toxic to healthy tissues than conventional anticancer drugs. TH-302 is the lead and only clinical stage product in our pipeline.  For additional information, please visit our website (www.thresholdpharm.com).

About TH-302
TH-302 is a hypoxia-targeted drug that is thought to be activated under tumor hypoxic conditions, a hallmark of many cancer indications. Areas of low oxygen levels (hypoxia) within tissues are common in many solid tumors due to insufficient blood vessel growth.

TH-302 has been investigated in over 600 patients in Phase 1/2 clinical trials to date in a broad spectrum of tumor types, both as a monotherapy and in combination with chemotherapy treatments and other targeted cancer drugs. Threshold has several additional ongoing clinical trials, the most advanced of which is a Phase 3 pivotal study evaluating TH-302 in combination with doxorubicin versus doxorubicin alone in patients with soft tissue sarcoma. More recently, Threshold completed a 215 patient randomized Phase 2 in combination with gemcitabine vs gemcitabine alone in advanced pancreatic cancer.  The initial results we presented at AACR earlier this year and a follow up will be presented at ESMO in late September.

In February 2012, Threshold signed a global agreement with Merck KGaA, Darmstadt, Germany, to co-develop and co-commercialize TH-302.

Clinical stage biotech with a solution for gene/protein delviery to cancer cells.

Tocagen is a private biopharma developing a unique retroviral replicating vector (RRV) platform that can efficiently delivery a gene or protein of choice selectively to cancer cells.

·         A fundamental challenge in oncology is to selectively deliver active agents to cancer cells while sparing healthy tissue.  We believe we may have found a solution.
·         Unlike oncolytic viruses, RRVs are unique because they replicate by budding-off from the host cancer cell which allows "stealth" spread through cancer tissue without being cleared by the immune system.
·         Our RRV system is capable of delivering genes such as those that code for prodrug activator enzymes, shRNA, or therapeutic proteins.
·         Our lead RRV product candidate, Toca 511, delivers a prodrug activator gene, cytosine deaminase (CD), selectively to cancer cells.
·         Toca 511 is used in combination with Toca FC, a proprietary formulation of 5-FC, that is converted in the presence of CD in infected cancer cells to 5-FU.
·         To date, Toca 511 & 5-FC has been dosed in 36 patients with high grade glioma in two ascending dose Phase I trials.
·         In addition to a promising safety and efficacy profile in patients, we have also accumulated data in patients supporting the anticipated mechanism of action for this approach
·         Now that we have clinical validation for our technology platform, we are interested in partnership discussions e.g. building new RRV constructs for the delivery of a gene or protein of interest to the partner.

More details about our technology can be found at www.tocagen.com and more information about our clinical trials can be found here: http://clinicaltrials.gov/ct2/results?term=tocagen

Tranzyme Pharma is a clinical-stage biopharmaceutical company focused on discovering, developing and commercializing novel, mechanism-based therapeutics for the treatment of upper gastrointestinal (GI) motility disorders. While approximately 40 percent of people in the U.S. are affected by these persistent and recurring conditions which disrupt the normal movement of food throughout the GI tract, there are a limited number of safe and effective treatment options. Tranzyme is developing TZP-102, an oral ghrelin agonist for treating the symptoms associated with chronic upper GI motility disorders. Enrollment is complete in a multinational Phase 2b trial evaluating TZP-102 given once daily in diabetic patients with gastroparesis; top-line data are expected by year-end 2012. Tranzyme has initiated a second Phase 2b trial (DIGEST) evaluating TZP-102 given prior to meals in diabetic patients with gastroparesis; top-line data are expected in the first half of 2013. By leveraging its proprietary drug discovery technology, MATCH™, Tranzyme is committed to pursuing first-in-class medicines to address areas of significant unmet medical needs.

Trius Therapeutics is a biopharmaceutical company focused on the discovery, development and commercialization of innovative antibiotics for life-threatening infections.

We have successfully completed our first Phase 3 clinical trial for Tedizolid Phosphate (TR-701), formerly torezolid phosphate, in ABSSSI. Tedizolid is an IV and orally administered second generation oxazolidinone, for the treatment of serious gram-positive bacterial infections, including those caused by methicillin-resistant Staphylococcus aureus (MRSA). With the continuous increase in bacterial resistance to currently marketed drugs, serious infections are becoming more difficult, if not impossible to treat, and this has led to a clear need for novel therapeutics to treat multi-drug resistant bacterial infections.

 Trius is headquartered in San Diego, California. 

Xcovery Vision is developing small molecule kinase inhibitors for opthamology indications. We have 4-5 canidates licensed exclusively to Xcovery Vision from Xcovery for the purpose of developing drugs for several eye diseases.

We are a spin out of Xcovery the parent oncology company founded by Sheridan Snyder founder of Genzyme and Dr. Chris Liang developer of Sutent, Pfizer's leading kidney cancer drug.

We are developing a oral drug for AMD which will be going into a Phase 1B trial this October. 

Please visit our website for more information www.xcoveryvision.com