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NanoSmart has developed and patented, a targeted drug delivery platform using human-derived, autoimmune antibodies capable of targeting many different kinds of tumors.  NanoSmart’s antitumor antibody, is not tumor-marker specific, but rather targets the areas of necrosis present in all solid tumors; including breast, lung, prostate, and rare cancers like Ewing’s Sarcoma.  Normal tissues do not have areas of necrosis and are not targeted.

NanoSmart is encapsulating off-patent FDA-approved drugs within liposomes coated with NanoSmart’s human-derived antibodies, thus creating an immunoliposome.  The liposome that encloses the active pharmaceutical ingredient protects healthy tissues while traveling to its target, and then slowly releases the drug over time.  NanoSmart’s antibody will then bind to the necrotic areas present in the middle of solid tumors and at the surrounding tumor site.

The end-result of using NanoSmart’s platform is a superior safety and efficacy profile for any drug that is adapted to our system.  Many different formulations can be developed by simply replacing one drug with another.  Each formulation is novel, patentable, and non-tumor specific (i.e. targets multiple cancers), and can be developed at a fraction of the cost and time typically associated with new drug development (i.e. IND to NDA in approximately 2-3 years).

Nektar Therapeutics is a clinical-stage biopharmaceutical company developing a pipeline of drug candidates that utilize its PEGylation and polymer conjugate technology platforms, which are designed to improve the benefits of drugs for patients. Its product pipeline consists of drug candidates across a number of therapeutic areas, including oncology, pain, anti-infectives, anti-viral and immunology. Nektar's research and development activities involve small molecule drugs, peptides and other potential biologic drug candidates. Its drug candidates are designed to improve the pharmacokinetics, pharmacodynamics, half-life, bioavailability, metabolism or distribution of drugs and improve the overall benefits and use of a drug for the patient.

Nektar is well-respected as a partner-of-choice with the world's leading pharmaceutical and biotechnology companies. Our platform technologies are validated and used in many of today's top-selling commercial drugs. As a result, industry returns to us time and time again to co-develop the next-generation of successful drugs designed to meet critical unmet medical needs.

Our strategic partnerships range from joint discovery and co-development to licensing and royalty arrangements with a wide range of organizations.

Novartis Oncology profile

 A business unit within the Novartis Group, Novartis Oncology delivers a broad range of innovative therapies and practical solutions that help change the way patients live with cancer and blood disorders. Glivec® (imatinib) is an oral treatment for multiple rare diseases including forms of Philadelphia-chromosome positive (Ph+) chronic myeloid leukemia (CML) and Kit (CD117)-positive gastrointestinal stromal tumors (GIST). Tasigna® (nilotinib) is approved for Ph+ CML adult patients resistant to or intolerant to at least one prior therapy. Afinitor® (everolimus) is indicated for patients with advanced renal cell carcinoma whose disease has progressed on or after treatment with vascular endothelial growth factor-targeted therapy. Zometa® (zoledronic acid) is indicated for the prevention of skeletal-related events in patients with advanced malignancies involving bone. Zometa also treats hypercalcemia of malignancy. Femara® (letrozole) is approved for adjuvant treatment of hormone receptor positive early breast cancer as well as for extended adjuvant treatment of hormone receptor positive early breast cancer after five years of initial tamoxifen therapy. It is also approved for several uses in certain postmenopausal women with advanced breast cancer. Sandostatin® LAR® (octreotide) helps control symptoms, such as severe diarrhea and flushing, associated with functional gastroenteropancreatic neuroendocrine tumors. It is also approved for the treatment of acromegaly. Exjade® (deferasirox) is approved to treat iron overload in a broad range of patients receiving ongoing blood transfusions. Novartis Oncology has a robust pipeline that utilizes recent discoveries in molecular genomics, rational drug design and state-of-the-art drug discovery technologies.

Partnering strategy

Novartis Oncology is seeking to license or acquire targeted therapeutic approaches to cancer treatment, with a particular interest in projects that have demonstrated Proof-of-Concept in human trials.

The Ono Pharmaceutical Group, in keeping with our philosophy of "Dedicated to Man's Fight against Disease and Pain," has always striven to serve as an R&D-oriented international pharmaceutical company.  In this endeavor we have placed our emphasis on creating innovative medicines that meet international requirements.  In addition to its own original research and development efforts, Ono has been very activly seeking a in-licensing opportunity from companies inside and outside Japan.

Principia Biopharma is building an integrated pharmaceutical company focused on the discovery and development of reversible covalent drugs for the treatment of autoimmune diseases and cancer.  Principia’s reversible covalent technology, which has been validated in vivo against multiple targets to date, produces molecules with superior attributes and our approach has significant advantages over standard drug development methods. 

o   It produces highly potent (low nanomolar to picomolar) compounds with increased selectivity and prolonged durability despite limited exposure.

o   Accelerates the drug development process by avoiding the need for HTS and the  provides the opportunity to evolve tool compounds into clinical candidates

o   Has a broad range of applicability across multiple target classes

Given the wealth of opportunities addressable with Principia’s technology, the company is interested in working with partners to fully exploit the technology outside of cancer and autoimmune therapeutic areas.

Fully Integrated Pharmaceutical Operations

Purdue provides partner companies with extensive expertise in discovery, clinical development, project management, regulatory affairs, manufacturing, marketing, and sales. A dedicated Alliance Management function ensures that every dimension and detail involved in our collaborations gets the attention required. Purdue has regulatory expertise and experience in gaining approval from the U.S. Food and Drug Administration (FDA). Our national U.S. sales and marketing organization has the critical mass and know-how to commercialize new products quickly and effectively.

Purdue Pharma and its independent associated companies (including the Mundipharma/Napp companies) have a presence in more than 30 countries and a staff of more than 5,000.  Each of these international companies is a leader within their respective market for key therapeutic areas.

Purdue has long-standing expertise in pain management and has transformed clinical practice to better serve the needs of patients with pain. We have conducted extensive pharma industry research into the development of analgesics that provide safe and effective pain relief to patients. We work extensively with physicians, opinion leaders, and patient advocacy groups to ensure that pain is appropriately recognized and treated.

Purdue and Shionogi & Co., Ltd., one of Japan’s largest research-based pharmaceutical companies, are collaborating on the discovery and development of new, non-opioid pain medications to treat pain. The research, which targets cellular receptors known to modulate pain responses, is being conducted jointly at Purdue’s research center in Cranbury, New Jersey, and Shionogi’s laboratories in Osaka, Japan.

Purdue has an exclusive U.S. licensing and co-promotion agreement with Labopharm Inc. of Laval, Canada for Ryzolt® (tramadol HCl extended-release tablets), an extended release formulation of tramadol.

Purdue has an exclusive license and collaboration agreement with Transcept Pharmaceuticals, Inc. to commercialize Intermezzo® (zolpidem tartrate sublingual tablet), a product for one type of insomnia.

Additionally, Purdue Pharma L.P. and its independent company, Mundipharma International Corporation Limited, entered into a global partnership with Infinity Pharmaceuticals, Inc. to advance the research, development, and commercialization of Infinity’s discoveries and early clinical programs in oncology (outside the United States) and neuropathic pain (worldwide).

Purdue’s licensing strategy seeks to identify late-stage products within the following therapeutic areas:

• Pain management – both non-opioids and opioids
• Sleep disorders
• Gastrointestinal disorders